To Cancer : Complementary and Integrative Therapies of Cancer.

Researchers at the University of Galway (Ireland) have discovered a substance capable of reducing the size of tumors because it inhibits an enzyme involved in DNA synthesis, according to an article published in the British science journal Nature Chemical Biology.

One characteristic of cancer cells is that their breed-dividend out of control, through DNA replication, which is multiplied by two and is divided into two new cells resulting.

In the early stages of this replication process involving the Cdc7 kinase enzyme, which activates through a group of proteins that trigger this process of copying genetic material.

The Irish team led by Corrado Santocanale has discovered a small molecule capable of inhibiting the action of this enzyme, preventing the multiplication of DNA and therefore the reproduction of cancer cells in patients suffering from tumors.

This substance acts against uncontrolled cell reproduction early in the process, compared with currently used chemotherapy, as it does in the final stages.

Moreover, another advantage shown by the researchers is that this molecule has a lower toxicity than current treatments of chemotherapy.

In experiments with laboratory mice with cancer, the inhibitor reduced the size of the tumor with lower toxicity levels, demonstrating that this enzyme is a target to be attacked to fight this disease.

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